KMID : 1235520120110020059
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Research in Vestibular Science 2012 Volume.11 No. 2 p.59 ~ p.63
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Immunohistochemical Study on ¥â1- and ¥â2-Adrenergic Receptors in Rat Vestibular Nuclei
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Ahn Seong-Ki
Roza Khalmuratova Hur Dong-Gu Kim Ho-Yeop Park Hyun-Woo Joo Yeon-Hee Kang Hung-Soo
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Abstract
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Background and Objectives : The aim of this study was to examine the localizations of ¥â1- and ¥â2-adrenergic receptors (ARs) in rat vestibular nuclei by immunohistochemical staining procedure.
Materials and Methods : Twelve male Sprague- Dawley rats were used in this study. Primary antibodies for the ¥â1- and ¥â2-ARs were used. The sections were treated with a biotinylated goat anti-rabbit antibody. The sections were then incubated in avidin-biotin-peroxidase reagent and processed with immunoperoxidase using 3.3¡¯-diaminobenzidine tetrahydrochloride.
Results: ¥â1-AR and ¥â2-AR immunopositive neurons were found to be distributed throughout the four major vestibular nuclei. Both receptors were primarily detected in neuronal somata and their proximal dendrites. ¥â1-AR and ¥â2-AR were moderately expressed in the superior vestibular nucleus, lateral vestibular nucleus, medial vestibular nucleus, and spinal vestibular nucleus.
Conclusion: The present study demonstrates, for the first time, that ¥â1-AR and ¥â2-AR receptors are localized in rat vestibular nuclei. Furthermore, this study may provide additional speculation into the role of ARs during vestibular signal processing. Further studies are needed to clarify the roles played by ¥â1-ARs and ¥â2-ARs through physiologic and functional studies.
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KEYWORD
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Migraine, Vertigo, Adrenergic receptor, Vestibular nuclei
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